Corresponding Author

Yan Li


Background Frailty-related issue is increasingly prominent with the acceleration of aging in China.However, domestic research on frailty is still in its infancy characterized by non-objective diagnosis basis, unclear pathogenesis and imperfect interventions.Objective To investigate the correlation of 25-hydroxyvitamin D and interleukin-6 with frailty in elderly patients with chronic disease in the stable phase,so asto explore objective diagnostic basis and new interventions for frailty. Methods A total of 152 inpatients (≥ 60 years old) with chronic disease in the stable phase were recruited from Department of Geriatrics,the First People's Hospital of Yunnan Province(hereinafter referred to as “the department of the hospital”) from November 2020 to April 2021. Clinic and laboratory data were collected. Comprehensive geriatric assessment was conducted via an internet-based platform of the Comprehensive Geriatric Assessment(inpatient version) developed by the department of the hospital,among which frailty was assessed by the Chinese version of Fried Frailty Phenotype,a component of the assessment scale. Results Among the 152 patients,47(30.9%) had no frailty,51(33.6%) had pre-frailty and 54(35.6%) had frailty. According to the binary Logistic regression analysis,disability〔OR=6.162,95%CI(1.091,34.789),P=0.039〕, 25-hydroxyvitamin D〔OR=0.901,95%CI(0.825,0.985),P=0.022〕 and interleukin-6〔OR=1.103,95%CI(1.012,1.201),P=0.025〕 were influencing factors for frailty in elderly patients with chronic disease in the stable phase. Conclusion Sufficient 25-hydroxyvitamin D may be associated with decreased risk of frailty and elevated interleukin-6 may be associated with increased risk of frailty in elderly patients with chronic disease in the stable phase. So these two indicators may be potential targets for predicting and treating frailty.

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