Relationship Between Heart Rate Variability and Distribution of Enlarged Perivascular Spaces in the Brain
The research investigated the relationship between heart rate variability（HRV）and the distribution of EPVSs in the brain. The rMMSD had a negative correlation with BG-EPVS severity score and a positive correlation with the EPVS dominance model，and was independently associated with the BG-EPVS severity score and EPVS dominance model， suggesting that an imbalance in the autonomic nervous system induced by declined rMMSD may cause blood-brain barrier disruption or reduced metabolic waste clearance in the brain，which may play a role in the pathophysiological mechanism of BG-EPVS formation.
Zhou, Dongyang; Chen, Jing; Lu, Chang; and Bai, Hongying
"Relationship Between Heart Rate Variability and Distribution of Enlarged Perivascular Spaces in the Brain,"
General Practice in China: Vol. 1:
2, Article 8.
Available at: https://www.gpinchina.net/journal/vol1/iss2/8